Immundnz shares insights you can use as inspiration or guidance in your Immune Modelling and Experimental Design projects. If you would like to discuss any of our shared materials or rather receive input on your ideas, we’re always open to start a conversation.
Learn how Immundnz guides Immune Modelling & Experimental Design
To study the role of heat shock proteins in immune-mediated cell death and autoimmunity, we designed a diabetes model consisting of transgenic expression of the target protein. We initiated cell death of islet beta-cells in a controlled dose-dependent manner. The study successfully revealed that the (i) initial beta cell death was responsible for initiating immune-mediated diabetes, and (ii) the immune response was increased by the overexpression of heat shock protein. This study was essential to understand the role of heat shock proteins in immunogenicity following tissue damage.
Learn how Immundnz guides Immune Risk Assessment
Vaccines against SARS-CoV-2 corona virus can be designed using the S protein, and also the entirety containing the M protein. The virus is suspected to cause cytokine storm in some patients. What is the possibility of any of these free proteins released from the vaccine to cause a serious adverse immune response?
Learn how Immundnz guides Tissue Damage Studies
In this case study, we look at tissue damage caused by commonly used drugs and if such damage is immunogenic.
Learn how Immundnz guides Immuno-Oncology & Toxicity research.
In this case study you can learn how we test the effect of an anti-cancer drug on M1 macrophage polarization and macrophage viability.
Learn how Immundnz guides Inflammation & Systemic Studies.
To test the ability of a compound to inhibit Th17 response in an inflammatory condition. We adopted our in-house human Th17 assay to test multiple formulations in a dose-dependent manner for inhibition of a Th17 response. TALL-1 cells differentiated and activated were treated with the formulations and measured for IL-17 and IL-22 by flow cytometry.
Learn how Immundnz guides Signalling Pathway Research
In this case study, we test the effect of a modified macrophage medium in inducing the differentiation of anti-tumour macrophages in cancer therapy.
Learn how Immundnz guides vaccine, drug delivery, and transfection research.
We adopted a cell line based dendritic cell (DC) model to transfer mRNA carried by a nanoparticle carrier. Both fluorescent and non-fluorescent protein products (load) were transferred as mRNA to assess translation and availability of proteins in DCs by flow cytometry.