Immunology Insights


Immundnz shares insights you can use as inspiration or guidance in your Immune Modelling and Experimental Design projects. If you would like to discuss any of our shared materials or rather receive input on your ideas, we’re always open to start a conversation.

Learn how Immundnz guides Immune Modelling & Experimental Design

To study the role of heat shock proteins in immune-mediated cell death and autoimmunity, we designed a diabetes model consisting of transgenic expression of the target protein. We initiated cell death of islet beta-cells in a controlled dose-dependent manner. The study successfully revealed that the (i) initial beta cell death was responsible for initiating immune-mediated diabetes, and (ii) the immune response was increased by the overexpression of heat shock protein. This study was essential to understand the role of heat shock proteins in immunogenicity following tissue damage. 

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Learn how Immundnz guides Immune Risk Assessment

Vaccines against SARS-CoV-2 corona virus can be designed using the S protein, and also the entirety containing the M protein. The virus is suspected to cause cytokine storm in some patients.  What is the possibility of any of these free proteins released from the vaccine to cause a serious adverse immune response?

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Learn how Immundnz guides Tissue Damage Studies

In this case study, we look at tissue damage caused by commonly used drugs and if such damage is immunogenic.

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Learn how Immundnz guides Immuno-Oncology & Toxicity research.

In this case study you can learn how we test the effect of an anti-cancer drug on M1 macrophage polarization and macrophage viability.

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Learn how Immundnz guides Inflammation & Systemic Studies.

To test the ability of a compound to inhibit Th17 response in an inflammatory condition. We adopted our in-house human Th17 assay to test multiple formulations in a dose-dependent manner for inhibition of a Th17 response. TALL-1 cells differentiated and activated were treated with the formulations and measured for IL-17 and IL-22 by flow cytometry.

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Learn how Immundnz guides Signalling Pathway Research

In this case study, we test the effect of a modified macrophage medium in inducing the differentiation of anti-tumour macrophages in cancer therapy.

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Learn how Immundnz guides vaccine, drug delivery, and transfection research.

We adopted a cell line based dendritic cell (DC) model to transfer mRNA carried by a nanoparticle carrier. Both fluorescent and non-fluorescent protein products (load) were transferred as mRNA to assess translation and availability of proteins in DCs by flow cytometry.

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Immune Modelling & Experimental Design

Immune Risk Assessment

Tissue Damage & Cytotoxicity

Immuno-Oncology & Immunotoxicity

Inflammation & Systemic Diseases

Vaccines, Drug Delivery & Transfection

Signalling Pathways

Looking for a tailored solution?

Of course, there is no one-size-fits-all solution for most studies. Immundnz specializes in developing tailored assays to enable you to challenge the status quo in your research.


Some of our popular assays

To accelerate your research and deliver high-quality data, Immundnz offers a broad spectrum of standardized, proven assays that are readily available.

M1/M2 Polarisation

M1/M2 are important in studies of various therapeutic areas and biological pathways.



Phagocytosis is an immunologic mechanism involved in apoptosis, necrosis, infection and tumour conditions mediated by leukocytes like macrophages, DCs, and neutrophils. 

Cytokine Release Assay

Cytokine release assay (CRA) is vital in biopharmaceutical discovery and development and life science research.


Dendritic Cell Maturation

Dendritic cells (DCs) are the star antigen-presenting cells (APCs) of myeloid or haematopoietic origin that play a vital role between the innate and adaptive immune systems. 


T Cell Differentiation

The T cell proliferation assay can be used to assess modulation of the T cell response by (immunomodulatory) compounds.


Immune & Protein-Based

We perform various immunologic and protein-based assays that are needed in your research or drug development.


Case Studies

Immundnz has performed many case studies, some of which are described here. You can always reach out to us for other examples of projects we have done.


Immundnz shares insights on in vitro immunology research for drug discovery on its blog, which is regularly updated by experts in the field.