Dendritic Cell Maturation assay

Dendritic cells (DCs) are the star antigen presenting cells (APCs) of myeloid or haematopoietic origin that play a key role between the innate and adaptive immune systems. DCs are pivotal in the T cell mediated T-helper response to MHC ClassII-Ag complex, and also cross presenting via the MHC ClassI pathway. They consist of receptors for pathogen and danger associated molecular patternse.g. TRL’s.

In vitro Dendritic Cell (DC) Maturation Studies

We generate DCs from a human monocytic cell line or derive DCs from primary monocytes or haematopoietic cells. These cells express CD11c, HLA-DR, CD80, CD86, SIRPa, CD14 and can be used in mono or co-cultures to study drug effects for DC maturation and various DC related outcomes. DCs can be characterised by flow cytometry, immunohistochemistry and microscopy and also through cytokine measurements. We can perform assays with a T cell line for immune functional studies.


DCs are very important in studies of various therapeutic areas and biological pathways:

  • Tumour biology and oncology
  • Wound healing
  • Infection
  • Inflammatory and autoimmune conditions
  • Cardiovascular disease
  • Tissue damage and cell death

In recent years much attention has been given to in vitro DC based models in cancer studies.

Looking For A Tailor-Made Solution?

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Immune Modelling & Experimental Design

Immune Risk Assessment

Tissue Damage & Cytotoxicity

Immuno-Oncology & Immunotoxicity

Inflammation & Systemic Diseases

Vaccines, Drug Delivery & Transfection

Signalling Pathways

Looking for a tailored solution?

Of course, there is no one-size-fits-all solution for most studies. Immundnz specializes in developing tailored assays to enable you to challenge the status quo in your research.


Some of our popular assays

To accelerate your research and deliver high-quality data, Immundnz offers a broad spectrum of standardized, proven assays that are readily available.

M1/M2 Polarisation

M1/M2 are important in studies of various therapeutic areas and biological pathways.



Phagocytosis is an immunologic mechanism involved in apoptosis, necrosis, infection and tumour conditions mediated by leukocytes like macrophages, DCs, and neutrophils. 

Cytokine Release Assay

Cytokine release assay (CRA) is vital in biopharmaceutical discovery and development and life science research.


Dendritic Cell Maturation

Dendritic cells (DCs) are the star antigen-presenting cells (APCs) of myeloid or haematopoietic origin that play a vital role between the innate and adaptive immune systems. 


T Cell Differentiation

The T cell proliferation assay can be used to assess modulation of the T cell response by (immunomodulatory) compounds.


Immune & Protein-Based

We perform various immunologic and protein-based assays that are needed in your research or drug development.


Case Studies

Immundnz has performed many case studies, some of which are described here. You can always reach out to us for other examples of projects we have done.


Immundnz shares insights on in vitro immunology research for drug discovery on its blog, which is regularly updated by experts in the field.