Immune Modelling & Experimental Design
Expert advisors in designing models for immune response studies, laboratory experiments and human in vitro systems.
Studies in experimental immunology commonly involve complex immune pathways that cannot be tested by single or standard assays. The designing of the experiment in a model is necessary with the consideration and knowledge of multiple factors in the signalling cascade, the interaction of multiple cells and their immunogenic or tolerogenic response.
Navigate and understand the complex immune system with a suitable immune model
An immune model is valuable for developing or testing an immuno-therapeutic expected to function by generating an immune response (e.g. against tumours), or if the drug targets an immune condition (e.g. autoimmunity) or if the drug might generate an adverse immune response.
The adaptive immune system is a complex system structured through a cascade of cells, receptors, and cytokines that process, respond, initiate, memorise, and deliver an immune response or tolerance. Therefore, understanding the threshold of ‘tolerance’, in addition to the innate immune components, is essential to determine the mechanism of a therapeutic that exerts its effect through an immune response or that is likely to cross paths with the immune system.
In a sterile inflammatory state, as in a drug-induced effect, the immune effectors interact with the body’s tissues and the therapeutic agent to produce a cell-mediated or antibody-mediated immunity.
Design experimental models for immune response
Pre-clinical assessment of drug efficacy or safety
Immuno oncology & inflammation studies
Human cell line-based model
In addition to the conventional PBMC-based approach, we have developed an in vitro human platform for (co-)cultures of human tissue and immune cells that can be customised to different drug modules to test drug immunomodulatory mechanism and/or immunologic risks. This platform is organic that evolves with our knowledge and experience in immunology.
Learn how Immundnz guides Immune Modelling & Experimental Design
To study the role of heat shock proteins in immune-mediated cell death and autoimmunity, we designed a diabetes model consisting of transgenic expression of the target protein. We initiated cell death of islet beta-cells in a controlled dose-dependent manner. The study successfully revealed that the (i) initial beta cell death was responsible for initiating immune-mediated diabetes, and (ii) the immune response was increased by the overexpression of heat shock protein. This study was essential to understand the role of heat shock proteins in immunogenicity following tissue damage.
Take a peek at our solutions.
We work very closely with our clients to understand and troubleshoot problems they might have had with previous pre-clinical experiments (in vivo or in vitro) or design a suitable experimental model to study the immunobiology associated with their product.
Immuno-oncology & Immuntoxicity
Immuno-oncological procedures hold the promise to eliminate the majority of tumors.
Immune Risk Assessment
Experts who help you generate critical information on immune drug safety in the pre-clinical phase that could be essential in the success of the drug.
Tissue Damage & Cytotoxicity
Cell culture systems are at the heart of our expertise and services. We grow various established and primary human cells in our lab that represent human tissue systems.
Inflammation & Systemic conditions
Expert consultants in designing models for immune response studies, laboratory experiments, and human in vitro Systems.
Vaccines, Drug Delivery & Transfection
Experts who help you generate critical information on immune drug safety in the pre-clinical phase that could be essential in the success of the drug.
Signalling Pathways
Cell culture systems are at the heart of our expertise and services. We grow various established and primary human cells in our lab that represent human tissue systems.
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