Signalling Pathways

Signalling pathways transform extracellular signals into cellular effects on transcription factor-mediated gene regulation. Extracellular information sensed at a cell’s surface must be converted into an intracellular response using a complicated network of interconnected signaling cascades. Cellular responses like proliferation, differentiation, secretion, and death are all regulated by these signaling events and thus essential aspects to investigate.



Map the key interactions that control cell activity and function and influence drug efficacy.

Kinase and other signaling enzyme activity assays are essential tools for researchers researching a broad range of signaling events. They are also commonly utilized in drug development applications to evaluate drug:target interactions. Immundnz helps to provide specific testable hypotheses to guide functional studies to identify critical regulators involved in drug development.

Learn how Immundnz guides Signalling Pathway Research

In this case study, we test the effect of a modified macrophage medium in inducing the differentiation of anti-tumour macrophages in cancer therapy.

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Looking For A Tailor-Made Solution?

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Immune Modelling & Experimental Design

Immune Risk Assessment

Tissue Damage & Cytotoxicity

Immuno-Oncology & Immunotoxicity

Inflammation & Systemic Diseases

Vaccines, Drug Delivery & Transfection

Signalling Pathways

Looking for a tailored solution?

Of course, there is no one-size-fits-all solution for most studies. Immundnz specializes in developing tailored assays to enable you to challenge the status quo in your research.


Some of our popular assays

To accelerate your research and deliver high-quality data, Immundnz offers a broad spectrum of standardized, proven assays that are readily available.

M1/M2 Polarisation

M1/M2 are important in studies of various therapeutic areas and biological pathways.



Phagocytosis is an immunologic mechanism involved in apoptosis, necrosis, infection and tumour conditions mediated by leukocytes like macrophages, DCs, and neutrophils. 

Cytokine Release Assay

Cytokine release assay (CRA) is vital in biopharmaceutical discovery and development and life science research.


Dendritic Cell Maturation

Dendritic cells (DCs) are the star antigen-presenting cells (APCs) of myeloid or haematopoietic origin that play a vital role between the innate and adaptive immune systems. 


T Cell Differentiation

The T cell proliferation assay can be used to assess modulation of the T cell response by (immunomodulatory) compounds.


Immune & Protein-Based

We perform various immunologic and protein-based assays that are needed in your research or drug development.


Case Studies

Immundnz has performed many case studies, some of which are described here. You can always reach out to us for other examples of projects we have done.


Immundnz shares insights on in vitro immunology research for drug discovery on its blog, which is regularly updated by experts in the field.