Inflammatory & Systemic Diseases
The immune system is central to responding to and mediating inflammatory, systemic or autoimmune conditions.
Inflammatory conditions may rise from pathogenic infections, injuries or metabolites from internal dysregulations. Systemic conditions may rise from genetic causes, dysregulated systems or certain intolerances in metabolic pathways. Therapeutics are targeted to neutralise or inhibit acute or chronic immune responses that are associated with innate immune (such as phagocytosis, macrophage polarisation) or specific T-helper pathways (such as Th1, Th2 or Th17).

Complex diseases requiring complex/customized assays and models
Systemic conditions may rise from genetic causes, dysregulated systems or certain intolerances in metabolic pathways. Therapeutics are targeted to neutralise or inhibit acute or chronic immune responses that are associated with innate immune (such as phagocytosis, macrophage polarisation) or specific T-helper pathways (such as Th1, Th2 or Th17).

Help in designing the right model to study inflammatory and systemic diseases

Depending on the MoA of the drug and the target tissue, the experimental model can involve several customised co-culture assays of immune cells and somatic cells

We have experience in diabetes, rheumatoid arthritis, atherosclerosis etc.
Working with Immundnz
Learn how Immundnz guides Inflammation & Systemic Studies.
To test the ability of a compound to inhibit Th17 response in an inflammatory condition. We adopted our in-house human Th17 assay to test multiple formulations in a dose-dependent manner for inhibition of a Th17 response. TALL-1 cells differentiated and activated were treated with the formulations and measured for IL-17 and IL-22 by flow cytometry.
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