Biomarker Analysis & Immune Proteomics

In our lab, mass spectrometry is an essential part of preclinical immunology and in vitro research for drug discovery and development. The technique can provide in-depth information about the regulation of the immune system and the molecular mechanisms involved in immune responses. Mass spectrometry-based proteomics is used in immunology research to study protein expression, (sub)cellular localization, secretion, protein modifications, and interactions in immune cells upon activation by different stimuli.

Immundnz develops and applies bioanalytical methods for use in immune proteomics and biomarker analysis in preclinical research. Available techniques are mass spectrometry (LC-MS) and immunoassays (ELISA). We employ these techniques in combination with multivariate analysis for biomarker identification such as proteomics and biomarker quantification and validation studies, especially in immunology and infection.

Immuno Proteomics

Immundnz is your provider of immunoproteomics services, the study of proteins involved in the immune response. Mass spectrometry in combination with multivariate analysis is used to identify proteins that are modulated by a specific  drug, disease or infection in comparison to a control group. Other applications of immunoproteomics include the identification of potential protein targets of antibodies and monitor purification by these antibodies and the characterization of MHC binding peptides. Inflammasomes are critical for the clearance of pathogens and damaged cells but, if uncontrollable, can also be a driver of autoimmune disease. Using a proteomics approach, components of the innate immune system that regulate inflammasomes can be identified and studied.


Biomarker Analysis

The quantitative analysis of protein biomarkers is performed to study e.g. immune response as a result of disease- or drug-induced tissue damage, secondary pathology and immunogenicity. We have absolute quantification assays for RAGE and TLR2/4 receptor proteins. These can be used e.g. to study the release of intracellular proteins to the extracellular matrix in in vitro studies.

Looking For A Tailor-Made Solution?

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Immune Modelling & Experimental Design

Immune Risk Assessment

Tissue Damage & Cytotoxicity

Immuno-Oncology & Immunotoxicity

Inflammation & Systemic Diseases

Vaccines, Drug Delivery & Transfection

Signalling Pathways

Looking for a tailored solution?

Of course, there is no one-size-fits-all solution for most studies. Immundnz specializes in developing tailored assays to enable you to challenge the status quo in your research.


Some of our popular assays

To accelerate your research and deliver high-quality data, Immundnz offers a broad spectrum of standardized, proven assays that are readily available.

M1/M2 Polarisation

M1/M2 are important in studies of various therapeutic areas and biological pathways.



Phagocytosis is an immunologic mechanism involved in apoptosis, necrosis, infection and tumour conditions mediated by leukocytes like macrophages, DCs, and neutrophils. 

Cytokine Release Assay

Cytokine release assay (CRA) is vital in biopharmaceutical discovery and development and life science research.


Dendritic Cell Maturation

Dendritic cells (DCs) are the star antigen-presenting cells (APCs) of myeloid or haematopoietic origin that play a vital role between the innate and adaptive immune systems. 


T Cell Differentiation

The T cell proliferation assay can be used to assess modulation of the T cell response by (immunomodulatory) compounds.


Immune & Protein-Based

We perform various immunologic and protein-based assays that are needed in your research or drug development.


Case Studies

Immundnz has performed many case studies, some of which are described here. You can always reach out to us for other examples of projects we have done.


Immundnz shares insights on in vitro immunology research for drug discovery on its blog, which is regularly updated by experts in the field.